Since 1998 CROss Alliance®, with the support of his Sponsors, has delivered more than 80 publications to the scientific community. This is our personal pride that proves, once more, the value and the reliability of our work in the clinical field.

2024

  • Di Fonzo V, Leuratti C, Sala F, Meroni M and Radicioni M, “Bioequivalence Study of a Newly Developed Ibuprofen Arginine 600 Mg Tablet Formulation versus Ibuprofen Arginine 600 Mg Granules in Healthy Volunteers”. Journal of Bioequivalence Studies, 2024 July. JBS

2023

  • Corrado M. E, Esposito M, Monico L, Piccolboni A, Tomasello M, “Analysis  of the EMA draft guidance “Guideline on computerised system and electronic data in clinical trials”. QUASAR, 2023 May. Quasar
  • Jing S, Yuan Y, Leuratti C, Vaja V, Cattaneo C,” Pharmacokinetic and Safety Study of Single and Multiple Oral Doses of Safinamide in Healthy Chinese Volunteers”. Clinical Pharmacology in Drug Development, 2023 June. Clinical Pharmacology in Drug Development
  • Corrado M. E, Esposito M, Monico L, Piccolboni A, Tomasello M, “Analysis of the EMA guidance “Guideline on computerised system and electronic data in clinical trials”. QUASAR, 2023 November. Quasar
  • Sun J, Zhang X, Wang L, Di Stefano AFD, Zanin V, Magrone P, Yuan Y, “Phase I study of the pharmacokinetics and safety of single and multiple doses of intravenous N-acetylcysteine in healthy Chinese subjects”, European Review for Medical and Pharmacological Sciences, 2023 December. ERMPS

2022

  • Radicioni M. M, Caverzasio C, Rovati S, Giori A.M, Cupone I, Marra F, Mautone G, “Comparative Bioavailability Study of a New Vitamin D3 Orodispersible Film Versus a Marketed Oral Solution in Healthy Volunteers”. Clinical Drug Investigation, 2022 Jan. Springer
  • Radicioni M. M, Leuratti C, Cometti B, “Randomized Pharmacokinetic Study of a Highly Purified Human Chorionic Gonadotropin and of a Recombinant Human Chorionic Gonadotropin Following Single Subcutaneous Administration in Healthy Women”. Clinical Drug Investigation, 2022 Jan. Springer
  • Di Stefano AFD, Radicioni M.M, Segantin A, Gentili A, Baroglio C, Marjanović I, Cattaneo C, “Randomised, 2-Sequence, 4-Period Replicate Cross-Over Bioequivalence Study of A New Riluzole Orodispersible Film Vs. A Reference Tablet in Healthy Volunteers”. Journal of Bioequivalence Studies, 2022 Apr. Annex Publishers
  • Lanini S, Milleri S, Andreano E, Nosari S, Paciello I, Piccini G, Gentili A, Phogat A, Hyseni I, Leonardi M, Torelli A, Montomoli E, Paolini A, Frosini A, Antinori A, Nicastri E, Girardi E, Plazzi M.M, Ippolito G, Vaia F, Della Cioppa G, Rappuoli R, “Safety and serum distribution of anti-SARS-CoV-2 monoclonal antibody MAD0004J08 after intramuscular injection”. NATURE Commun. 13, 2022 Apr. Nature Communications
  • Di Stefano AFD, Radicioni M.M, Morano F, Gentili A, Mallat E, Cuomo D, Mazzarella T, Di Fonzo V, “Fosfomycin Pharmacokinetic Profile in Plasma and Urine and Quantitative Estimation in Prostate and Seminal Vesicles after One and Two Consecutive Doses of Oral Fosfomycin Trometamol in Healthy Male Volunteers”. Antibiotics, 2022 Oct. MDPI
  • Queille-Roussel C, Morano F, Di Stefano AFD, Babbi P, Perego M, “Bioequivalence Study of a Novel Clobetasol Propionate Topical gel 0.05% using the Vasoconstriction Bioassay”. Journal of Bioequivalence & Bioavailability, Dec 2022. Walsh Medical Media.

2021

  • Di Stefano A. F. D, Radicioni M. M, Vaccani A, Mazzetti A, Longo L.M, Moro L,” Pharmacokinetics and Safety of Rifamycin SV after Single and Multiple Doses of MMX® Modified Release Tablets in Healthy Male and Female Volunteers”. MDPI, 2021 Feb, 10(2), 167. MDPI
  • Sulyok I, Camponovo C, Zotti O, Haslik W, Köstenberger M, Likar R, Leuratti C, Donati E, Kimberger O, “A randomised, non-inferiority study of chloroprocaine 2% and ropivacaine 0.75% in ultrasound-guided axillary block”. Sci Rep. 2021 May; 11(1). PubMed

2020

  • Di Stefano A. F. D, Radicioni M. M, Vaccani A, Caccia G, Focanti F, Salvatori E, Pelacchi F, Picollo R, Rosignoli M. T, Olivieri S, Bovi G, and Comandini A, “Antimycotic Vaginal Ovule Combining Econazole and Benzydamine”. Hindawi Publishing Corporation, 2020 May; 11 pages. Hindawi
  • Tellone V, Rosignoli MT, Picollo R, Dragone P, Del Vecchio A, Comandini A, Radicioni M, Leuratti C, Calisti F, “Effect of 3 Single Doses of Trazodone on QTc Interval in Healthy Subjects”. J Clin Pharmacol, 2020 June. PubMed
  • Papi A, Di Stefano A. F. D, Radicioni M. M, “Pharmacokinetics and Safety of Single and Multiple Doses of Oral N-Acetylcysteine in Healthy Chinese and Caucasian Volunteers: An Open-Label, Phase I Clinical Study”. Advances in Therapy, 2020 November. Springer

2019

  • Corrado M, Vitali E, Valsecchi G, “Electronic patient records in the context of clinical research”. Quasar #147. 2019 Apr; 20-23. QUASAR 
  • Leuratti C, Loprete L, Rossini M, Frangione V, Rovati S, Radicioni M, “Pharmacokinetics and Safety of a Diclofenac Sodium 75 mg/1 mL Solution (Akis®/Dicloin®) Administered as a Single Intravenous Bolus Injection in Healthy Men and Women”. Eur J Drug Metab Pharmacokinet. 2019 May. PubMed

2018

  • Loprete L, Leuratti C, Frangione V, Radicioni M, “Pharmacokinetics of a Novel Sildenafil Orodispersible Film Administered by the Supralingual and the Sublingual Route to Healthy Men”. Clinical Drug Investigation. June 2018. PubMed
  • Di Stefano AF, Radicioni M, Vaccani A, Fransioli A, Longo L, Moro L, Repici A, “Methylene blue MMX® tablets for chromoendoscopy. Bioavailability, colon staining and safety in healthy volunteers undergoing a full colonoscopy”. Contemporary Clinical Trials August 2018. PubMed
  • Radicioni M, Koirala R, Fiore W, Leuratti C, Guglielmetti S, Arioli S, “Survival of L. casei DG® (Lactobacillus paracasei CNCMI1572) in the gastrointestinal tract of a healthy paediatric population”. European Journal of Nutrition. November 2018. Springer

2017

  • Radicioni M, Castiglioni C, Giori A, Cupone I, Frangione V, Rovati S, “Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers”. Dove Medical Press. 2017 Apr. 10:41-48. Dovepress
  • Di Salvo A, Busechian S, Zappulla F, Marchesi MC, Pieramati C, Orvieto S, Boveri M, Predieri PG, Rueca F, Della Rocca G, “Pharmacokinetics and tolerability of a new formulation of omeprazole in the horse”. J Vet Pharmacol Ther. 2017 Aug. 40:348-355. WOL

2016

  • Loprete L, Leuratti C, Cattaneo C, Thapar M M, Farrel C, Sardina M, “Population pharmacokinetic and pharmacodynamic analyses of safinamide in subjects with Parkinson’s disease”. Pharmacology Research & Perspectives. 2016 Oct; 4. WOL
  • Delgado JL, Estevez J, Radicioni M, Loprete L, Moscoso del Prado J, Nieto Magro C, “Pharmacokinetics and preliminary efficacy of two vaginal gel formulations of ultra-low-dose estriol in postmenopausal women”. Climacteric. 2016 Apr; 19:172-80. PubMed
  • Caserini M, Radicioni M, Leuratti C, Terragni E, Iorizzo M, Palmieri R, “Effect of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia”. International Journal of Clinical Pharmacology and Therapeutics. 2016; 54:19-27. PubMed
  • Di Stefano AF, Rusca A, Radicioni MM, Loprete L, Binelli D, Caccia G, Cometti B, “Pharmacokinetics and Pharmacodynamics of Follicle-Stimulating Hormone in Healthy Women Receiving Single and Multiple Doses of Highly Purified Human Menotrophin and Urofollitrophin”. Clin Drug Investig. 2016 Sep. PubMed

2015

  • Mario E. Corrado, “Switzerland Guides Innovation in Clinical Trial Regulations”. Applied Clinical Trials. 2015 Dec; 24:18-21. ACT
  • Seng Yue C1, Benvenga S, Scarsi C, Loprete L, Ducharme MP, “When Bioequivalence in Healthy Volunteers May not Translate to Bioequivalence in Patients: Differential Effects of Increased Gastric pH on the Pharmacokinetics of Levothyroxine Capsules and Tablets”. J Pharm Pharm Sci. 2015 Dec; 18:844-55. PubMed
  • Di Stefano AF, Spinetti G, Rusca A, Radicioni MM, Loprete L, Lamparelli DM, Michael Hepp J, Crobu D, Schrepfer R, Tonon G, “Recombinant filgrastim (BK0023) pharmacodynamics and pharmacokinetics after single and multiple escalating doses in an equivalence study in healthy men”. Clin Drug Investig. 2015 Sep; 35:533-45. PubMed

2014

  • Loprete L, Leuratti C, Scarsi C, Radicioni M, “Pharmacodynamics and Pharmacokinetics of a Novel, Low-Dose, Soft-Gel Capsule of Acetylsalicylic Acid in Comparison with an Oral Solution After Single-Dose Administration to Healthy Volunteers: A Phase I, Two-Way Crossover Study. ” Clin Drug Investig. 2014 Jan; 34:19-25. PubMed
  • Travis S P L, Danese S, Kupcinskas L, Alexeeva O, D’Haens G, Gibson P R, Moro L, Jones R, Ballard E D, Masure J, Rossini M, Sandborn W J, “Once-daily budesonide MMX in active, mild-to-moderate ulcerative colitis: results from the randomised CORE II study.” Gut. 2014; 63:433-441. Gut
  • Di Stefano A F D, Radicioni M M, Vele A, Mancarella Eberhardt A, Caccia G, Focanti F, Salvatori E, “Tolerability and hydrating effects of an anti-aging gynaecological collagen cream in women in menopause” OJOG. 2014 Feb; Vol.4, No.3. OJOG
  • Crobu D, Spinetti G, Schrepfer R, Tonon G, Jotti GS, Onali P, Dedoni S, Orsini G, Di Stefano A, “Preclinical and clinical phase I studies of a new recombinant Filgrastim (BK0023) in comparison with Neupogen®.” BMC Pharmacol Toxicol. 2014 Feb; 15(1):7. BMC
  • Wenisch JM, Mayr FB, Spiel AO, Radicioni M, Jilma B, Jilma-Stohlawetz P, “Androgen deprivation decreases prostate specific antigen in the absence of tumor: implications for interpretation of PSA results.” Clin Chem Lab Med. 2014 Mar; 52:431-6. PubMed
  • Caserini M, Radicioni M, Leuratti C, Annoni O, Palmieri R, “A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects on plasma androgen levels in healthy male volunteers.” Int J Clin Pharmacol Ther. 2014 Oct; 52(10):842-9. PubMed

2013

  • Monti D, Herranz U, Dal Bo L, Subissi A. “Nail penetration and predicted mycological efficacy of an innovative hydrosoluble ciclopirox nail lacquer vs. a standard amorolfine lacquer in healthy subjects.” J Eur Acad Dermatol Venereol. 2013 Feb; 27:153-8. PubMed
  • Paragona M, Rossini M, Dattilo M; Stamm W. “LH supplementation in mild stimulations cycles without pituitary suppression. A retrospective analysis.” Gynecological Endocrinology, 2013 Feb; 29:101-4. PubMed
  • Radicioni M, Connolly S, Stroppolo F, Granata G, Loprete L, Leuratti C, “Bioequivalence study of a novel orodispersible tablet of meloxicam in a porous matrix after single-dose administration in healthy volunteers.” Int J Clin Pharmacol Ther. 2013 Mar; 51:234-43. PubMed
  • Sator M, Radicioni M, Cometti B, Loprete L, Leuratti C, Schmidl D, Garhöfer G. “Pharmacokinetics and safety profile of a novel progesterone aqueous formulation administered by the s.c. route. ” Gynecol Endocrinol. 2013 Mar; 29:205-8. PubMed
  • Radicioni M, Cremonesi G, Baraldi E, Leuratti C, Mariotti F. “Pharmacokinetic and tolerability of i.m. disodium clodronate 200 mg/lidocaine 1%, given twice monthly, in comparison with i.m. disodium clodronate 100 mg/lidocaine 1%, given weekly, in healthy postmenopausal female patients.” Int J Clin Pharmacol Ther. 2013 Apr; 51:313-22. PubMed
  • Govoni M, Poli G, Acerbi D, Santoro D, Cicirello H, Annoni O, Ružička J. “Pharmacokinetic and tolerability profiles of tobramycin nebuliser solution 300 mg/4 ml administered by PARI eFlow(®) rapid and PARI LC Plus(®) nebulisers in cystic fibrosis patients.” Pulm Pharmacol Ther. 2013 Apr; 26:249-55. PubMed
  • Di Stefano AF, Radicioni MM, Rusca A. “Pressor Response to Oral Tyramine and Monoamine Oxidase Inhibition During Treatment with Ralfinamide (NW-1029).” Neurotox Res. 2013 May; 23:315-26. PubMed
  • De Ziegler D, Sator M, Binelli D, Leuratti C, Cometti B, Bourgain C, Fu YS, Garhöfer G. A randomized trial comparing the endometrial effects of daily subcutaneous administration of 25 mg and 50 mg progesterone in aqueous preparation. Fertil Steril. 2013 Sep; 100:860-6. PubMed
  • A.F.D. Di Stefano, D. Binelli, W. Labuschagne, M. Mojapelo, E. van der Walt, S. Patel and L. Moro “Efficacy of the Treatment of Infectious Diarrhoea with Non-Absorbable Rifamycin SV Formulated as MMX Modified Release Tablet vs. Rifaximin” Anti-Infective Agents, 2013, vol.11, 192-203. Bentham Science
  • Leuratti C, Sardina M, Ventura P, Assandri A, Müller M, Brunner M., “Disposition and Metabolism of Safinamide, a Novel Drug for Parkinson’s Disease, in Healthy Male Volunteers.” Pharmacology. 2013 Oct; 92:207-16. PubMed
  • Burian A, Frangione V, Rovati S, Mautone G, Leuratti C, Vaccani A, Crevenna R, Keilani M, Burian B, Brunner M, Zeitlinger M. “An exploratory microdialysis study investigating the effect of repeated application of a diclofenac epolamine medicated plaster on prostaglandin concentrations in skeletal muscle after standardized physical exercise.” Br J Clin Pharmacol. 2013 Dec; 76:880-7. PubMed

2012

  • Matzneller P, Burian A, Martin W, Annoni O, Lauro V, Tacchi R, Brunner M, Zeitlinger M. “A Randomised, Two-Period, Cross-Over, Open-Label Study to Evaluate the Pharmacokinetic Profiles of Single Doses of Two Different Flurbiprofen 8.75-mg Lozenges in Healthy Volunteers.” Pharmacology. 2012; 89:188-91. PubMed
  • A. Repici, A.F.D. Di Stefano, M.M. Radicioni, V. Jas, L. Moro, S. Danese “Methylene blue MMX® tablets for chromoendoscopy. Safety tolerability and bioavailability in healthy volunteers” Contemporary Clinical Trials. 2012 Mar; 33:260-267. ScienceDirect
  • Zeitlinger M, Rusca A, Oraha AZ, Gugliotta B, Müller M, Ducharme MP. “Pharmacokinetics of a new diclofenac sodium formulation developed for subcutaneous and intramuscular administration.” Int J Clin Pharmacol Ther. 2012 Jun; 50:383-90. PubMed

2011

  • Di Stefano AF, Rusca A, Loprete L, Dröge MJ, Moro L, Assandri A. “Rifamycin SV systemic absorption in healthy volunteers administered as modified release MMX(R) tablets”. Antimicrob Agents Chemother. 2011 May; 55:2122-2128. PubMed
  • Brunner M, Davies D, Martin W, Leuratti C, Lackner E, Müller M. A new topical formulation enhances relative diclofenac bioavailability in healthy male subjects. Br J Clin Pharmacol. 2011 Jun; 71:852-9. PubMed
  • Wagner CC, Rusca A, Kletter K, Tschurlovits M, Pace S, Longo A, Pedrani M, Villa R, Frimonti E, Müller M, Brunner M.”Plasma pharmacokinetics and gastrointestinal transit of a new Propionyl-l-Carnitine controlled release formulation”. Department of Clinical Pharmacology, Medical University of Vienna , Vienna , Austria. Xenobiotica. 2011 Nov; 41:988-995. PubMed
  • A.F.D. Di Stefano, A. Rusca. “Pressor response to oral tyramine during co-administration with salfinamide in healthy volunteers” Naunyn-Schmiedeberg’s Arch Pharmacol 2011 Dec; 384:505-515. PubMed
  • Singh D, Collarini S, Poli G, Acerbi D, Amadasi A, Rusca A. “Effect of AeroChamber Plus™ on the lung and systemic bioavailability of beclometasone dipropionate/formoterol pMDI.” Br J Clin Pharmacol. 2011 Dec; 72:932-939. PubMed

2010

  • Corrado M.E. Great Expectations: changes for contract research organisations (CROs) in Italy Publication. Quasar, Journal of the British Association of Quality Assurance, BARQA, April 2010; 111: 24-26.
  • Marberger M, Kaisary AV, Shore ND, Karlin GS, Savulsky C, Mis R, Leuratti C, Germa JR. “Effectiveness, pharmacokinetics, and safety of a new sustained-release leuprolide acetate 3.75-mg depot formulation for testosterone suppression in patients with prostate cancer: a Phase III, open-label, international multicenter study.” Clin Ther. 2010 Apr;32(4):744-57. PubMed
  • Rosignoli MT, Di Loreto G, Dionisio P. “Effects of prulifloxacin on cardiac repolarization in healthy subjects: a randomized, crossover, double-blind versus placebo, moxifloxacin-controlled study”. Clin Drug Investing. 2010;30(1):5-14. PubMed
  • G.R. D’Haens, Á. Kovács, P. Vergauwe, F. Nagy, T. Molnár, Y. Bouhnik, W. Weiss, H. Brunner, A. Lavergne-Slove, D. Binelli, A.F.D. Di Stefano and P. Marteau. Clinical trial: “Preliminary efficacy and safety study of a new Budesonide-MMX® 9 mg extended-release tablets in patients with active left-sided ulcerative colitis”. Journal of Crohn’s and Colitis Volume 4, Issue 2, June 2010, Pages 153-160. PubMed
  • Bauer M, Bliesath H, Leuratti C, Lackner E, Dieterle W, Müller M, Brunner M. Disposition and Metabolism of Ralfinamide, a Novel Na-Channel Blocker, in Healthy Male Volunteers. Pharmacology. 2010 Nov 11;86(5-6):297-305. PubMed

2009

  • Rusca A, Di Stefano AF, Doig MV, Scarsi C, Perucca E. “Relative bioavailability and pharmacokinetics of two oral formulations of docosahexaenoic acid/eicosapentaenoic acid after multiple-dose administration in healthy volunteers.” Eur J Clin Pharmacol. 2009 Jan 16. PubMed
  • Lindstedt R, Ruggiero V, D’Alessio V, Manganello S, Petronzelli F, Stasi MA, Vendetti S, Assandri A, Carminati P, De Santis R. “The immunosuppressor st1959, a 3,5-diaryl-s-triazole derivative, inhibits T  cell activation by reducing NFAT nuclear residency.” Int J Immunopathol Pharmacol. 2009 Jan-Mar;22(1):29-42. PubMed
  • Saletu-Zyhlarz GM, Anderer P, Wolzt M, Semlitsch HV, Assandri A, Nessi P, Nannnipieri F, Rosini S, Rosini S, Saletu B “Double-Blind, Placebo-Controlled, Multiple-Ascending-Dose Study on the pharmacodynamics of ABIO-08/01, a New CNS Drug with Potential Anxiolytic Activity. 1. EEG Mapping, Psychometric and Tolerability Findings.” Neuropsychobiology. 2009 Apr 10;59(2):100-109. PubMed
  • Saletu B, Anderer P, Wolzt M, Nosiska D, Assandri A, Noseda E, Nannipieri F, Saletu-Zyhlarz GM “Double-Blind, Placebo-Controlled, Multiple-Ascending-Dose Study on the Pharmacodynamics of ABIO-08/01, a New CNS Drug with Potential Anxiolytic Activity. 2. EEG-Tomography Findings Based on LORETA (Low-Resolution Brain Electromagnetic Tomography)” Neuropsychobiology. 2009 Apr 10;59(2):110-122. PubMed
  • Shore N.D., Savulsky C., Mis R., Karlin G., Marberger M., Leuratti C., Kaisary A. “Phase III efficacy and safety trial of a new leuprolide acetate 3.75 mg depot formulation in prostate cancer patients.” Publication-only abstracts issured by ASCO Annual ’09 Meeting.
  • Corrado M.E. “Great Expectations: CROs Face Change in Italy”, Applied Clinical Trials, November 2009; 18 (11): 50-54.

2008

  • Anderer P, Saletu B, Wolzt M, Culic S, Assandri A, Nannipieri F, Rosini S and Saletu-Zyhlarz G.M, “Double-blind, placebo-controlled, multiple-ascending-dose study on the effects of ABIO-08/01, a novel anxiolytic drug, on perception and cognition, utilizing event-related potential mapping and low-resolution brain electromagnetic tomography” Hum. Psychopharmacol. 2008 Apr.23(3):243-54. PubMed
  • Leitner J.M, Mayr F.B, Spiel A.O, Firbas C, Savulsky C, Mis R, Corrado M.E. and Jilma B, The pharmacokinetics and pharmacodynamics of a new sustained release leuprolide acetate depot compared to the market reference. Int. J. Clin. Pharmacol and Ther. 2008. 46 (8): 407-414. PubMed
  • Cerabolini R, Boissard G, Buonfiglio T, Savorelli M.P, “Children faces with the aerosol therapy. Compliance’s inhalation therapy observation (study) when aerosol is administered with a device equipped with educational games for children 5-8 years.” Ricerche di Psicologia, 3/2008.
  • Corrado M.E “CPD – A participant’s perspective”, Quasar, Journal of the British Association of Quality Assurance. BARQA. July 2008. 104: 32-33.
  • Rusca A, Mautone G, Sun S, Magelli M, Johnson F, “Comparison of plasma pharmacokinetics of FLECTOR Patch (diclofenac epolamine topical patch) and oral Voltaren (diclofenac sodium enteric-coated tablets) in healthy volunteers”. Journal of Pain. April 2008. JPain

2007

  • Minghetti P, Cilurzo F, Pagani S, Casiraghi A, Assandri R, Montanari L “Formulation study of oxybutynin patches”. Pharm Dev Technol. 2007;12(3):239-46. PubMed
  • Poli G, Acerbi D, Pennini R, Soliani Raschini A, Corrado ME, Eichler HG, Eichler I, “Clinical pharmacology study of Bramitob, a tobramycin solution for nebulization, in comparison with Tobi, Paediatr Drugs”, 2007;9 Suppl 1:3-9. PubMed

2006

  • Stuebner P, Horak F, Zieglmayer R, Arnaiz E, Leuratti C, Perez I, Izquierdo I. “Effects of rupatadine vs placebo on allergen-induced symptoms in patients exposed to aeroallergens in the Vienna Challenge Chamber”. Ann Allergy Asthma Immunol. (2006), 96,37-44. PubMed
  • Bauer M, Langer O, Dal-Bianco P, Karch R, Brunner M, Abrahim A, Lanzenberger R, Hofmann A, Joukhadar C, Carminati P, Ghirardi O, Piovesan P, Forloni G, Corrado ME, Lods N, Dudczak R, Auff E, Kletter K, Muller M. “A positron emission tomography microdosing study with a potential antiamyloid drug in healthy volunteers and patients with Alzheimer’s disease”. Clin Pharmacol 2006 80(3):216-27. PubMed

2003-05

  • Brunner M, Assandri R, Kletter K, Tschurlovits M, Corrado ME, Villa R, Eichler HG, Muller M. “Gastrointestinal transit and 5-ASA release from a new mesalazine extended-release formulation”. Aliment Pharmacol Ther. (2003). 17, 395-402. PubMed
  • Brunner M, Greinwald R, Kletter K, Kvaternik H, Corrado ME, Eichler HG, Muller M. “Gastrointestinal transit and release of 5-aminosalicylic acid from 153Sm-labelled mesalazine pellets vs. tablets in male healthy volunteers”. Aliment Pharmacol Ther. (2003) 17 1163-9. PubMed
  • Horak F, Stübner P, Zieglmayer R, Kavina A, Corrado EM, Assandri A and Mion A. “Study of the therapeutic efficacy and safety of emedastine difumarate versus cetirizine in the treatment of seasonal allergic rhinitis”. Arzneim.-Forsch./Drug Res. 54, 666-672(2004). PubMed
  • Corrado EM, Radicioni MM, Hartwig J, Assandri A, Oldeman HG, and Mion A. “Clinical study of the therapeutic efficacy and safety of emedastine difumarate versus terfenadine in the treatment of seasonal allergic rhinitis”. Arzneim.-Forsch./Drug Res. 54, 660-665(2004). PubMed
  • Poli G, Mariotti F, Corrado ME, Acerbi D. “A tolerability and pharmacokinetic study of a new injectable formulation of disodium clodronate in healthy female volunteers”. Eur J Drug Metab Pharmacokinet. 2004, 29,145-52. PubMed
  • Arnold O, Saletu B, Anderer P, Assandri A, di Padova C, Corrado M, Saletu-Zyhlarz GM. “Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry”. Eur Neuropsychopharmacol. (2005)15, :533-43. PubMed
  • Brunner M, Ziegler S, Di Stefano AF, Dehghanyar P, Kletter K, Tschurlovits M, Villa R, Bozzella R, Celasco G, Moro L, Rusca A, Dudczak R, Muller M. “Gastrointestinal transit, release and plasma pharmacokinetics of a new oral budesonide formulation”. Br J Clin Pharmacol. (2005) ,61, 31-38. PubMed
  • Valle M, Barbanoj MJ, Donner A, Izquierdo I, Herranz U, Klein N, Eichler HG, Muller M, Brunner M. “Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers”. Eur J Clin Pharmacol. (2005), 61, 103-11. PubMed

2001 - 02

  • Herranz U, Rusca A, Assandri A, “Emedastine-ketoconazole: pharmacokinetic and pharmacodynamic interactions in healthy volunteers”. Int J Clin Pharmacol Ther 2001;39:102-9. PubMed
  • Joukhadar C, Herranz U, Pernerstorfer T, Assandri A, Klein N, Schrolnberger C, Lackner E, Eichler HG, Muller M; “Pharmacokinetics of emedastine difumarate, a new anti-histaminic agent in patients with renal impairment”. Eur J Clin Pharmacol 2001 Mar;56(12):905-10. PubMed
  • Brunner M, Kletter K, Assandri A, Corrado ME, Eichler HG, Muller M. “Pharmacokinetic and mass balance study of unlabelled and (14)C-labelled emedastine difumarate in healthy volunteers.” Xenobiotica 2002;32:761-70. PubMed
  • Saletu B, Anderer P, Linzmayer L, Semlitsch HV, Lindeck-Pozza E, Assandri A, di Padova C, Saletu-Zyhlarz GM. “Pharmacodynamic studies on the central mode of action of S-adenosyl-L-methionine infusions in elderly subjects, utilizing EEG mapping and psychometry”, J Neural Transm 2002 ;109:1505-26. PubMed
  • P. Anderer, B. Saletu, HV Semlitsch, A. Assandri, C. Di Padova, W. Prause, E. Lindeck-Pozza, G.M. Saletu-Zyhlarz ” Acute and sub-acute, double-blind, placebo-controlled studies on the effects of S-adenosyl-L-methionine on information” processing by ERP-mapping and LORETA International Congress Series 1232 (2002)237-241.
  • Saletu-Zyhlarz GM, Anderer P, Linzmayer L, Semlitsch HV, Assandri A, Prause W, Hassan Abu-Bakr M, Lindeck-Pozza E, Saletu B. Visualizing central effects of S-adenosyl-L-methionine (SAMe), a natural molecule with antidepressant properties, by pharmaco-EEG mapping. Int J Neuropsychopharmacol 2002 Sep;5(3):199-215. PubMed
  • Saletu B, Anderer P, Di Padova C, Assandri A, Saletu-Zyhlarz GM. “Electrophysiological neuroimaging of the central effects of S-adenosyl-L-methionine by mapping of electroencephalograms and event-related potentials and low-resolution brain electromagnetic tomography.” Am J Clin Nutr. 2002 Nov;76(5):1162S-71S. PubMed

1998 - 00

  • Muller M, Rastelli C, Ferri P, Jansen B, Breiteneder H, Eichler HG. “Transdermal penetration of diclofenac after multiple epicutaneous administration”. J Rheumatol 1998 ;25:1833-1836. PubMed
  • B. Saletu, P. Anderer, A. Assandri, W. Orazse, M. Abu-Bakr, E. Lindeck-Pozza, G.M. Saletu-Zyhlarz: “Proving central effects of the nutraceutical and supplementary substance S-adenosyl-L-methionine (ademetionine) by pharmaco-EEG mapping”. Textbook of the training course of the 11th Biennial Congress of Pharmaco EEG, Vienna 2000.
  • Jansen B, Graselli U, Dallinger S, Kiss B, Wacheck V, Schlagbauer-Wadl H, Assandri A, Muller M. “Pharmacokinetics and pharmacodynamics of the novel H1-receptor antagonist emedastine in healthy volunteers”. Eur J Clin Pharmacol 2000 Feb-;55:837-41. PubMed