Cardiac safety

The long QT syndrome is a disease of myocardial ion channels that manifests clinically as recurrent syncope or cardiac arrest due to malignant ventricular arrhythmias. Health Authorities issued a specific guideline while protocols satisfying the regulatory demand have been designed.

CROss Alliance™ as acquired a specific expertise in QTc prolongation studies performed in HV and in cooperation with ERT (leading provider for cardiac safety), is able to offers a full service QTc prolongation study compliant with the different US and EU regulatory requests.

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1) Rosignoli MT, Di Loreto G, Dionisio P. "Effects of prulifloxacin on cardiac repolarization in healthy subjects: a randomized, crossover, double-blind versus placebo, moxifloxacin-controlled study". Clin Drug Investing. 2010;30(1):5-14.

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