Since 1996 your fastest track for Phase I trials...

CROSS Research is licensed for Phase I studies to be carried out in healthy volunteers and special populations with the aim of assessing drug safety, kinetics and disposition; establishing kinetic-dynamic relationships; measuring drug time-course of action, identify the proper therapeutic dose regimens and fulfil the regulatory requests.
Strategic services as: centralised clinical lab, analytical labs for drug assay and pharmaceutical labs for implementing formulation technology are co-operating with CROss Alliance™ on the basis of preferential contracts and long term collaboration history.

Safety studies

  • Single ascending dose tolerability and pharmacokinetics, (SAD)
  • Multiple dose tolerability and pharmacokinetics, (MAD)
  • Local tolerability and sensitisation potential
  • Photo-toxicity and photo-sensitisation
  • Evaluation of gastro-intestinal tolerability of drugs assessed by: gastroscopy, colonoscopy, sugars permeability or pH-metry
  • QTc prolongation studies
  • Drug-drug interaction studies, (DDI)

Clinical pharmacokinetics

  • Single and Multiple dose pharmacokinetics
  • Bioavailability and Bioequivalence
  • Effect of meal
  • Effect of exercise
  • Pharmacokinetics in elderly
  • Pharmacokinetics in post-menopausal women

Special studies

  • Skin-adhesiveness study for new patches development including objective computerised measurements
  • Cations and anions binders effectiveness within the GI tract for drug development in nephropathy
  • Induction of ketone bodies: a model for anti-diabetic drugs
  • Cheese-effect for MAO inhibitors screening
  • Medical device testing in healthy volunteers with experience in: pneumology, gynaecology, dermatology
  • Studies on nutraceuticals, (ask us for more information about the fast track available for studies with these products)


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All the “pathways” to get in touch with CROSS. Feel free to contact us for any additional information you may need, we will be glad to assist you in the shortest time possible.

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